Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols
نویسندگان
چکیده
منابع مشابه
Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols.
Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes usi...
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General Information. Commercial reagents were purified prior to use following the guidelines of Perrin and Armarego. Organic solutions were concentrated under reduced pressure on a Büchi rotary evaporator. Chloroform was distilled from calcium hydride prior to use. Chromatographic purification of products was accomplished using forced-flow chromatography on ICN 60 32-64 mesh silica gel 63 accor...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2018
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.7b12768